منابع مشابه
mRNP granules
Messenger ribonucleoprotein (mRNP) granules are dynamic, self-assembling structures that harbor nontranslating mRNAs bound by various proteins that regulate mRNA translation, localization, and turnover. Their importance in gene expression regulation is far reaching, ranging from precise spatial-temporal control of mRNAs that drive developmental programs in oocytes and embryos, to similarly exqu...
متن کاملCytoplasmic mRNP granules at a glance.
Introduction From their transcriptional birth to their degradation, cellular mRNAs are coated with proteins in messenger ribonucleoprotein (mRNP) complexes. The mRNP composition controls every aspect of the life of the mRNA, from pre-mRNA processing to mRNA localization, translation and turnover. Transitions between these events are accompanied by major mRNP remodeling and exchange of mRNP prot...
متن کاملStress granules and processing bodies are dynamically linked sites of mRNP remodeling
Stress granules (SGs) are cytoplasmic aggregates of stalled translational preinitiation complexes that accumulate during stress. GW bodies/processing bodies (PBs) are distinct cytoplasmic sites of mRNA degradation. In this study, we show that SGs and PBs are spatially, compositionally, and functionally linked. SGs and PBs are induced by stress, but SG assembly requires eIF2alpha phosphorylation...
متن کاملMaternal mRNAs are regulated by diverse P body–related mRNP granules during early Caenorhabditis elegans development
Processing bodies (P bodies) are conserved mRNA-protein (mRNP) granules that are thought to be cytoplasmic centers for mRNA repression and degradation. However, their specific functions in vivo remain poorly understood. We find that repressed maternal mRNAs and their regulators localize to P body-like mRNP granules in the Caenorhabditis elegans germ line. Surprisingly, several distinct types of...
متن کاملCo‐transcriptional mRNP formation is coordinated within a molecular mRNP packaging station in S. cerevisiae
In eukaryotes, the messenger RNA (mRNA), the blueprint of a protein-coding gene, is processed and packaged into a messenger ribonucleoprotein particle (mRNP) by mRNA-binding proteins in the nucleus. The steps of mRNP formation - transcription, processing, packaging, and the orchestrated release of the export-competent mRNP from the site of transcription for nuclear mRNA export - are tightly cou...
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ژورنال
عنوان ژورنال: RNA Biology
سال: 2014
ISSN: 1547-6286,1555-8584
DOI: 10.4161/15476286.2014.972208